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‘Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle’

by Hans Daetwyler and many colleagues has just been published online (see http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3034.html).

The project is often described as the 1000 bull genomes project which aims to support the acceleration of the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase reported this month, the whole genomes of 234 cattle were sequenced to an average of 8.3-fold coverage. The data included 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. A total of 28.3 million variants were identified and a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia were reported.

 

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